Wet granulation forms by bindinthe powders together with an adhesive, instead of by compaction. bridges are developed between the particles and the tensile strength of bonds increases as the amount of liquid added is increased. Wet granulation involves the massing of a mix of dry primary powder particles using a granulating fluid.The fluid contains a solvent which can be removed by drying, and should be non-toxic.Typical solvents include water, ethanol and isopropanol and methylene chloride either alone or in combination. The granulation liquid may be used alone or, more usually, as a solvent containing a dissolved binder / suspension / gelatinized binder. (also referred to as a binder or binding agent) which is used to ensure particle adhesion once the granule is dry.